Global Configuration UI is there to engage modules at global level. When you engage a module globally, this configuration will be applied for all the services hosted in the server. You can use it to control all the services identically with a particular module.
In the above UI, available modules are shown first and currently engaged modules are shown in the lower part. WS-Addressing module is always globally engaged. In addition to that, this list will be updated when you engage other available modules.
For example, throttle module is available to be configured globally. Once you click on the green color icon to engage throttling, the UI shown below will be appeared and you can configure throttling using this UI.
After you have engaged a module (for example, throttling), the Global Configuration UI will be updated as shown below. The icon in front of an already engaged module, will indicate a red mark to tell you that it can be disengaged or reconfigured by clicking on that icon.